Jove
Visualize
Contact Us

Related Experiment Videos

Necrotizing funisitis: a study of 45 cases.

S M Jacques1, F Qureshi

  • 1Department of Pathology, Hutzel Hospital, Detroit, MI 48201.

Human Pathology
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes.

IJTLD open·2024
Same author

Gastrointestinal bleeding among hospitalizations for salicylate poisoning in the United States.

QJM : monthly journal of the Association of Physicians·2021
Same author

Analysis of Reasons for Orthopaedic Walkouts from the Emergency Department in a Private Tertiary Care Centre.

Malaysian orthopaedic journal·2021
Same author

Correlation of serum protein biomarkers with disease activity in psoriatic arthritis.

Expert review of clinical immunology·2020
Same author

Methotrexate for papuloerythroderma of Ofuji.

Clinical and experimental dermatology·2019
Same author

Reliability of the International Spinal Cord Injury Musculoskeletal Basic Data Set.

Spinal cord·2016
Same journal

TRPS1 and GATA3 Expression in BRG1/SMARCA4-deficient Malignant Neoplasms.

Human pathology·2026
Same journal

Clinicopathologic and Molecular Characteristics of Acral Melanomas Harboring RARA Fusions.

Human pathology·2026
Same journal

Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors.

Human pathology·2026
Same journal

Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

Human pathology·2026
Same journal

Mixed Phenotype Acute Leukemia: Lineage Assignment, Immunophenotypic Classification and Genetic Insights.

Human pathology·2026
Same journal

Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype.

Human pathology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Necrotizing funisitis (NF) is an umbilical cord inflammation. This study found NF is likely polymicrobial, not solely linked to syphilis, and associated with other pregnancy complications.

Area of Science:

  • Perinatal pathology
  • Obstetrics
  • Infectious disease

Background:

  • Necrotizing funisitis (NF) is an umbilical cord inflammation with unclear etiology.
  • Some research links NF to syphilis, while others find no consistent infectious agents.

Purpose of the Study:

  • To investigate the relationship between necrotizing funisitis and syphilis.
  • To identify other potential causes and associated factors of NF.

Main Methods:

  • Retrospective analysis of 45 cases of necrotizing funisitis.
  • Review of maternal syphilis testing (Rapid Plasma Reagin, Fluorescent Antibody Absorption Test).
  • Examination of placental histology, maternal/fetal cultures, and clinical data.

Main Results:

Related Experiment Videos

  • Only 11% of mothers had confirmed syphilis; no syphilis was found in infants born to mothers without syphilis.
  • Prolonged rupture of membranes (62%) was the most frequent maternal factor.
  • Acute chorioamnionitis was present in 100% of cases; chronic villitis was noted in 58%.

Conclusions:

  • Necrotizing funisitis likely has a polymicrobial etiology.
  • NF alone should not be presumptive of syphilis without other supporting placental findings.
  • Factors causing NF may also contribute to preterm labor, premature rupture of membranes, and stillbirth.