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Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6
T Yi1, D J Gilbert, N A Jenkins
1Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Genomics
|November 1, 1992
Abstract:
Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.