Related Experiment Video
Updated: Jun 24, 2026

12:47
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
Published on: March 21, 2014
FACILITATION: ELECTRICAL RESPONSE ENHANCED BY CONDITIONAL EXCITATION OF CEREBRAL CORTEX
Abstract:
Cats were conditioned to give a foot flexion in response to stimulation of the brain through implanted electrodes. The evoked electrical activity of an extracallosal interhemispheric pathway was much greater in the repeatedly stimulated direction than in the unstimulated direction in the brain. No difference in the two directions was observed in control animals that did not receive the unconditional foot shock.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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