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Published on: June 23, 2020

LINCOMYCIN AND STAPHYLOCOCCAL INFECTIONS: A CLINICAL STUDY OF 18 CASES

C GRONDIN, M ST-MARTIN, A POTVIN

    Canadian Medical Association Journal
    |May 15, 1965
    PubMed

    Insights

    Lincomycin, a new antibiotic, shows high effectiveness against Staphylococcus aureus infections, including chronic osteomyelitis. Clinical trials indicate it is well-tolerated with minimal side effects like loose stools.

    Area of Science:

    • Microbiology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Gram-positive bacterial infections pose significant therapeutic challenges.
    • Staphylococcus aureus is a common pathogen responsible for various infections.
    • Novel antibiotics are crucial for combating resistant bacterial strains.

    Purpose of the Study:

    • To evaluate the efficacy and safety of lincomycin against Gram-positive organisms.
    • To assess lincomycin's effectiveness in treating staphylococcal infections, particularly chronic osteomyelitis.
    • To identify potential toxicities and side effects associated with lincomycin treatment.

    Main Methods:

    • In vitro susceptibility testing of lincomycin against Gram-positive bacteria.
    • Clinical evaluation of lincomycin in patients with staphylococcal infections.
    • Monitoring for adverse events and treatment outcomes in a series of 18 patients.

    Main Results:

    • Lincomycin demonstrated significant in vitro activity against Staphylococcus aureus.
    • Clinical trials showed lincomycin to be effective and well-tolerated in 18 patients.
    • Nine cases of chronic osteomyelitis, including a 15-year-unresponsive case, showed pronounced effectiveness.
    • The primary side effect observed was occasional loose stools.

    Conclusions:

    • Lincomycin is a promising new antibiotic for treating Gram-positive infections, especially those caused by Staphylococcus aureus.
    • Its effectiveness in challenging cases like chronic osteomyelitis warrants further investigation.
    • Lincomycin presents a favorable safety profile with minimal gastrointestinal side effects.
    Keywords:
    ABSCESSANTIBIOTICSARTHRITIS, INFECTIOUSDRUG RESISTANCE, MICROBIALDRUG THERAPYFURUNCULOSISLINCOMYCINOSTEOMYELITISSTAPHYLOCOCCAL INFECTIONSTOXICOLOGIC REPORT

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