Macrodactyly of the hands and feet

Sixteen patients with macrodactyly have been reviewed; the hand was involved in 9 (one was bilateral) and the feet in 7. The condition was familial in 3. No qualitative difference was found between the static and progressive types. In the hand, the digital nerve was enlarged and lengthened whereas in the foot it looked normal. Microscopy showed infiltration of the nerve by fat and fibrous tissue in the hand and only slight perineural fibrosis in the foot.