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L-tryptophan supplementation does not improve running performance.

T Stensrud1, F Ingjer, H Holm

  • 1Laboratory of Physiology, Norwegian University of Sport and Physical Education, Oslo.

International Journal of Sports Medicine
|August 1, 1992
PubMed
Summary
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L-Tryptophan (L-TRY) supplementation did not improve running performance in well-trained male runners. A randomized controlled trial found no significant difference compared to placebo, suggesting L-TRY does not enhance exercise capacity.

Area of Science:

  • Sports Science
  • Nutritional Biochemistry
  • Human Performance

Background:

  • Previous research suggested L-Tryptophan (L-TRY) supplementation enhanced exercise duration.
  • Acute performance improvements in human studies are rare.
  • Potential adverse effects of L-TRY necessitate further investigation.

Purpose of the Study:

  • To replicate and verify the findings of Segura and Ventura regarding L-TRY and exercise performance.
  • To investigate the effects of L-TRY supplementation on endurance running capacity in trained athletes.

Main Methods:

  • A randomized, double-blind, placebo-controlled study involving 49 well-trained male runners.
  • Subjects completed treadmill tests to determine maximal oxygen uptake (VO2max) and anaerobic threshold.

Related Experiment Videos

  • Participants underwent two exhaustion trials at 100% VO2max, with one following 24-hour L-TRY or placebo ingestion.

    • Main Results:

    • No statistically significant difference in running performance was observed between the L-TRY and placebo groups.
    • The study did not replicate the performance enhancement reported in earlier research.

    Conclusions:

    • Oral L-Tryptophan supplementation does not appear to enhance running performance in well-trained male athletes.
    • Further research may be needed to explore potential mechanisms or specific conditions where L-TRY might affect performance.