Related Experiment Videos
FMOC solid phase synthesis of an endothelin converting enzyme substrate. Use of allyl ester as the third orthogonal
1Department of Physical Methods, Roche Products Limited, Welwyn Garden City, Hertfordshire, England.
International Journal of Peptide and Protein Research
|July 1, 1992
Abstract:
The synthesis of a substrate for the endothelin converting enzyme using the continuous flow FMOC solid phase method has been accomplished. The allyl group, employed to protect Glu side chain, was cleanly removed during the synthesis in the presence of tert.-butyl based protecting groups to enable the introduction of the Edans moiety. The substrate was obtained in 31% yield after reverse phase hplc purification.