Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pattern ERG in glaucoma: effect of pattern reversal time.

P Mierdel1, H J Zenker, E Marré

  • 1Eye Clinic, Medical Academy Carl Gustav Carus, Dresden, Germany.

International Ophthalmology
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanism of the growth-promoting action of fusicoccin : Interaction with auxin, and effects of inhibitors of respiration and protein synthesis.

Planta·2014
Same author

Cation-activated ATPase activity of plasmalemma-enriched membrane preparations from maize coleoptiles.

Planta·2013
Same author

Ocular optical aberrometer for clinical use.

Journal of biomedical optics·2001
Same author

Increased higher-order optical aberrations after laser refractive surgery: a problem of subclinical decentration.

Journal of cataract and refractive surgery·2001
Same author

Principles of Tscherning aberrometry.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2000
Same author

Clinical experience with the Tscherning aberrometer.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2000

Transient pattern electroretinograms (PERG) show delayed responses with ramp-like reversals in glaucoma patients. This latency shift, unlike amplitude, effectively differentiates between glaucoma and normal vision.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Pattern electroretinograms (PERG) assess retinal function.
  • Glaucoma can affect visual pathway temporal processing.
  • Ramp-like pattern reversals elicit delayed PERG responses compared to abrupt reversals.

Purpose of the Study:

  • To investigate the utility of PERG latency shifts in detecting early to moderate glaucoma.
  • To compare the diagnostic power of amplitude versus latency measures in glaucoma detection.

Main Methods:

  • Transient PERGs were recorded from 20 glaucomatous eyes and normal subjects.
  • A pattern reversal stimulator with adjustable reversal periods was utilized.
  • Stimulation involved both step-like (abrupt) and ramp-like temporal courses.

Related Experiment Videos

Main Results:

  • No significant difference in P1 amplitude between glaucoma and normal groups with step-like stimulation.
  • Highly significant separation (P < 0.0001) between groups using P1 latency with ramp-like stimulation.
  • Significant latency shift between step and ramp-like stimulation identified glaucomatous eyes.

Conclusions:

  • PERG latency, particularly the shift between stimulation types, is a sensitive biomarker for early and moderate glaucoma.
  • Latency measures offer superior diagnostic capability over amplitude in this context.
  • Temporal processing deficits in the retina are detectable using ramp-like PERG stimulation in glaucoma.