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Paediatric renal transplantation in Ireland: 1980-1990
G Thomas1, P J Conlon, S Spencer
1Department of Paediatric Renal Medicine, Children's Hospital, Dublin.
Insights
Pediatric renal transplantation outcomes show good patient survival but highlight challenges in graft survival, especially for children with congenital kidney diseases. Further research is needed to improve long-term graft success rates.
Area of Science:
- Pediatric Nephrology
- Transplantation Surgery
- Immunology
Background:
- Renal transplantation is a vital treatment for end-stage renal disease in children.
- Understanding outcomes in pediatric renal transplant recipients is crucial for improving care.
- Previous studies have focused on adult populations, necessitating specific pediatric data.
Purpose of the Study:
- To analyze the outcomes of renal transplantation in a pediatric cohort.
- To identify primary renal diseases and donor types in children undergoing transplantation.
- To evaluate patient and graft survival rates in pediatric renal transplant recipients.
Main Methods:
- Retrospective analysis of 862 renal transplants performed between 1980 and 1990.
- Inclusion of 38 pediatric patients (46 transplants) with a mean age of 8.6 years.
- Categorization of primary renal diseases and donor sources (70% cadaveric).
Main Results:
- Reflux nephropathy (39%), congenital disorders (30%), and glomerulonephritis (16%) were leading causes of renal failure.
- One-year patient survival was 90%, and one-year graft survival was 61%.
- Seven children received a second graft, achieving a 71% one-year graft survival.
Conclusions:
- Pediatric renal transplantation demonstrates favorable patient survival rates.
- Graft survival rates require improvement, particularly in the context of primary congenital kidney diseases.
- Second graft survival in children is encouraging, suggesting potential for re-transplantation.
Abstract:
Between 1980 and 1990, 862 renal transplants were performed at our unit. Forty-six of these were given to 38 children. The mean age of the children was 8.6 years. Reflux nephropathy accounted for 39% of the primary renal diseases, followed by congenital disorders (30%), and glomerulonephritis (16%). Seventy percent of the grafts were from cadaveric donors. The one year patient survival was 90%, and the one year graft survival 61%. Seven children received a second graft with a one year graft survival of 71%.