Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities
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H Takahashi1, H Osada, H Koshino
1Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
The Journal of Antibiotics
|September 1, 1992
Abstract:
Reveromycins A, B, C and D showed inhibitory activity against EGF-stimulated mitogen response in Balb/MK cells. Furthermore reveromycins A, C and D exhibited morphological reversion of srcts-NRK cells, antiproliferative activity against human tumor cell lines and antifungal activity. The effects of reveromycins A, C and D on eukaryotic cells were closely similar to each other, but those of reveromycin B were very weak. In vitro studies revealed that reveromycin A is a selective inhibitor of protein synthesis in eukaryotic cells.