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Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity
K Sugawara1, Y Nishiyama, S Toda
1Bristol-Myers Squibb Research Institute, Tokyo, Japan.
The Journal of Antibiotics
|September 1, 1992
Abstract:
Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.