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Plasma exchange versus an affinity column for cholesterol reduction.

E A Burgstaler1, A A Pineda

  • 1Section of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota 55905.

Journal of Clinical Apheresis
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Dextran sulfate cellulose bead affinity column (DSAC) systems offer effective cholesterol reduction comparable to plasma exchange (PE) but with significantly less high-density lipoprotein (HDL) loss.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Homozygous hypercholesterolemia type IIA is a severe genetic disorder characterized by extremely high LDL cholesterol levels.
  • Selective removal systems offer an alternative to traditional plasma exchange (PE) for managing such conditions.

Observation:

  • A 10-year study compared PE with normal serum albumin (NSA) or hydroxyethyl starch (HES) replacement against single and double dextran sulfate cellulose bead affinity column (DSAC) systems.
  • Treatment involved a male patient with homozygous hypercholesterolemia type IIA.

Findings:

  • Both PE and double DSAC systems achieved comparable reductions in total cholesterol and LDL+VLDL levels.
  • DSAC systems demonstrated a 53% lower reduction in high-density lipoprotein (HDL) compared to PE methods.
  • Average total cholesterol reduction was 55% for double DSAC versus 57-59% for PE methods.

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Implications:

  • DSAC systems provide an effective alternative for cholesterol reduction in severe hypercholesterolemia.
  • The reduced HDL loss with DSAC systems may offer a more favorable lipid profile outcome.
  • These findings support the use of selective apheresis technologies in managing genetic lipid disorders.