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Analysis of antiepileptic drugs in human plasma using micellar electrokinetic capillary chromatography
1Organic Analytical Laboratory, Korea Research Institute of Standards and Science, Daejonsi, Daeduk Science Town.
Journal of Chromatography
|September 11, 1992
Abstract:
We describe a method for the simultaneous determination of antiepileptic drugs (ethosuccimide, phenytoin, primidone, phenobarbital, carbamazepine and valproic acid) by micellar electrokinetic capillary chromatography using sodium dodecyl sulphate as the micellar phase. Factors affecting the micellar electrokinetic separation were studied for the quantitative determination of these drugs in human plasma. The confirmation of the peaks and the specificity of the method were investigated by combining multiwavelength detection with micellar electrokinetic capillary chromatography.