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'Chemical curettage' using intrauterine methotrexate injection
H Strohmer1, A Boldizsar, W Feichtinger
1Institute of Sterility Treatment, Vienna, Austria.
Human Reproduction (Oxford, England)
|August 1, 1992
Summary
A woman with a rare uterine anomaly experienced a second blighted ovum. Transvaginal methotrexate injection successfully terminated the intrauterine pregnancy, offering a new treatment option.
Area of Science:
- Reproductive Medicine
- Gynecology
- Medical Case Study
Background:
- A 22-year-old woman with uterine anomalies presented with a blighted ovum in a rudimentary uterine horn.
- Previous management of a similar condition involved prostaglandin therapy.
Observation:
- Dilatation and curettage was not feasible due to horn inaccessibility.
- The patient had a history of a previous blighted ovum treated with prostaglandin.
Findings:
- Transvaginal, intrauterine instillation of 100 mg methotrexate resulted in complete abortion.
- This method was effective despite the challenging anatomical location.
Implications:
- Local methotrexate injection may be a viable alternative for terminating intrauterine pregnancies in specific complex cases.
- This approach offers a potential treatment for pregnancies in non-communicating or rudimentary uterine horns.
- Further research into local methotrexate efficacy for intrauterine pregnancy termination is warranted.