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Related Experiment Videos

Tissue artefacts caused by sponges.

D J Farrell1, P J Thompson, A R Morley

  • 1Department of Histopathology, Freeman Hospital, Newcastle upon Tyne.

Journal of Clinical Pathology
|October 1, 1992
PubMed
Summary
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Triangular artefacts in renal and liver biopsies are caused by foam sponges in embedding cassettes. These artefacts distort tissue, impairing interpretation and requiring careful identification during histological analysis.

Area of Science:

  • Histopathology
  • Biopsy Processing
  • Materials Science

Background:

  • Processing small biopsy specimens is crucial for accurate diagnosis.
  • Artefacts during tissue processing can lead to misinterpretation and diagnostic errors.
  • Previous studies have highlighted various sources of artefacts in histopathology.

Purpose of the Study:

  • To identify the cause of triangular artefacts observed in renal and liver biopsy specimens.
  • To investigate the role of embedding cassette foam sponges in artefact formation.
  • To correlate microscopic findings of artefacts with the structure of foam sponges.

Main Methods:

  • Observation of triangular artefacts in renal and liver biopsy tissues.
  • Examination of foam sponges from embedding cassettes used during specimen processing.

Related Experiment Videos

  • Scanning electron microscopy (SEM) analysis of foam sponge structure.

    • Main Results:

    • Triangular artefacts were consistently observed in processed renal and liver biopsy specimens.
    • SEM revealed that the foam sponges consist of a mesh of rigid, scimitar-shaped spikes.
    • The morphology of the spikes in the foam sponges directly correlated with the shape of the observed tissue artefacts.

    Conclusions:

    • Foam sponges within embedding cassettes are the source of triangular artefacts in small biopsy specimens.
    • These artefacts can distort tissue morphology, potentially affecting diagnostic accuracy.
    • Understanding the origin of these artefacts is essential for improving biopsy processing techniques and diagnostic reliability.