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Abnormal haemoglobin electrophoresis caused by BW 12C
F van Rhee1, I Ware, T Littlewood
1Department of Haematology, John Radcliffe Hospital, Headington, Oxford.
Journal of Clinical Pathology
|October 1, 1992
Abstract:
BW 12C, a substituted benzaldehyde, stabilises haemoglobin in the oxy-conformation and has attracted interest as an anti-sickling agent. The drug causes a left shift in the oxygen saturation curve and may induce tumour anoxia and enhance the effect of cytotoxic drugs. During clinical trials in patients with cancer abnormal bands on haemoglobin electrophoretic strips were observed. This made correct diagnosis of abnormal haemoglobins impossible. Solubility tests for sickling disorders (Itano) also proved unreliable.