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Topical treatment of Old World cutaneous leishmaniasis caused by Leishmania major: a double-blind control study
J el-On1, S Halevy, M H Grunwald
1Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of The Negev, Beer Sheva, Israel.
Background:
A controlled study of the efficacy of topical paromomycin sulfate (PR) and methylbenzethonium chloride (MBCl) in cutaneous leishmaniasis (CL) has not yet been performed.
Objective:
The therapeutic effect of an ointment containing 15% PR and either 12% or 5% MBCl (15/12 or 15/5 P-ointment) on patients suffering from Old World CL was examined in a randomized, double-blind, cross-over study.
Methods:
Thirty-nine patients with Old World CL caused by Leishmania major were treated topically, twice daily, for 10 to 20 days with 15/12 or 15/5 P-ointment and 10 to 20 days with a placebo ointment to achieve a total of 30 days of treatment in all groups.
Results:
In the P-ointment-treated groups, 74.2% (29 of 39 patients) of the patients were cured versus 26.6% (4 of 15 patients) in the placebo-treated group. Little difference was found between the 15/12 and 15/5 P-ointment groups.
Conclusion:
In most of the patients treated with the active ingredients, total elimination of the parasites was achieved within the first 10 days of treatment.