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Malignant tumors in patients with psoriasis
Journal of the American Academy of Dermatology
|November 1, 1992
Summary
Psoriasis patients face a significantly higher risk of nonmelanoma skin cancer and certain other cancers, including lung, larynx, pharynx, colon, and kidney cancers. Antipsoriatic treatments may contribute to the increased risk of colon cancer.
Area of Science:
- Dermatology and Oncology
- Epidemiology of Cancer Risk
Background:
- Existing evidence links psoriasis treatments to increased nonmelanoma skin cancer risk.
- Potential association between psoriasis therapies and other cancer types requires further investigation.
Purpose of the Study:
- To investigate cancer incidence in a large cohort of Danish patients with psoriasis.
- To compare observed cancer rates in psoriasis patients with national population data.
Main Methods:
- Utilized the Danish National Hospital Discharge Register to identify 6910 psoriasis patients.
- Obtained cancer case data from the Danish Cancer Registry.
- Compared patient cancer incidence against expected rates for the general population.
Main Results:
- Observed a 2.5-fold increased risk for nonmelanoma skin cancer in both men and women.
- Identified elevated risks for lung cancer (men and women), larynx and pharynx cancer (men), and colon and kidney cancer (women).
Conclusions:
- Antipsoriatic treatments, including ionizing radiation and oral arsenicals, are potential contributors to excess colon cancer risk.
- The study could not assess the impact of cigarette smoking on noncutaneous cancer risk.