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Folates and post partum depression.

F Rouillon1, M Thalassinos, H D Miller

  • 1Hôpital Louis Mourier, Service de Psychiatrie, Colombes, France.

Journal of Affective Disorders
|August 1, 1992
PubMed
Summary
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Low folate levels (hypofolatemia) after delivery do not predict postpartum depression or baby blues. Previous psychiatric history, however, was linked to postpartum depression in mothers.

Area of Science:

  • Reproductive Psychiatry
  • Nutritional Neuroscience

Background:

  • Hypofolatemia, a condition of low folate levels, is associated with depressive psychiatric disturbances.
  • Pregnancy and childbirth are periods often linked with hypofolatemia.
  • The potential role of hypofolatemia as a risk factor for postpartum mood disorders requires investigation.

Purpose of the Study:

  • To investigate whether hypofolatemia on day 3 postpartum is a risk factor for developing 'baby blues' or postpartum depression.
  • To assess the relationship between folate levels and maternal mood disorders in the early postpartum period.

Main Methods:

  • A prospective study followed 131 postpartum women for three months after delivery.
  • Serum and erythrocyte folate levels were measured on day 3 postpartum.

Related Experiment Videos

  • Maternal mood was assessed using Pitt's scale for 'baby blues' and the QD2A scale for postpartum depression.

    • Main Results:

    • No statistically significant relationship was found between folate levels on day 3 postpartum and scores for 'baby blues' or postpartum depression.
    • 19% of participants experienced 'baby blues' and 12% experienced postpartum depression within three months.
    • A significant correlation was observed between postpartum depression and a history of psychiatric disturbance.

    Conclusions:

    • Hypofolatemia on day 3 postpartum is not a significant risk factor for 'baby blues' or postpartum depression.
    • Previous psychiatric history is a notable risk factor for postpartum depression.
    • Further research may explore other potential contributing factors to postpartum mood disorders.