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Related Concept Videos

Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

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Related Experiment Video

Updated: Jul 28, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

[Dynamics of synaptic changes in experimental audiogenic epilepsy].

J Dymecki, H Karwacka, M Walski

    Neurologia I Neurochirurgia Polska
    |January 1, 1977
    PubMed
    Summary

    Epileptic seizures cause synaptic vesicle depletion, with recovery dependent on seizure frequency and time. Chronic epilepsy leads to degenerative synaptic changes, potentially underlying epileptic dementia.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Pathology

    Context:

    • Epilepsy is a neurological disorder characterized by recurrent seizures.
    • Ultrastructural changes in neuronal synapses are implicated in neurological disorders.
    • Audiogenic epilepsy in mice and rats provides a model for studying seizure-induced neuronal alterations.

    Purpose:

    • To investigate the ultrastructural dynamics of axonal endings following experimental epileptic seizures.
    • To correlate seizure frequency and post-seizure survival time with synaptic vesicle changes.
    • To examine synaptic alterations in both acute and chronic experimental epilepsy models.

    Summary:

    • Acute seizures, particularly serial ones, led to significant synaptic vesicle depletion in hippocampal synapses.

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    Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
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    Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

    Published on: January 20, 2023

    Related Experiment Videos

    Last Updated: Jul 28, 2026

    Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
    09:07

    Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

    Published on: August 15, 2017

    Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
    10:24

    Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

    Published on: May 15, 2018

    Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
    09:49

    Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

    Published on: January 20, 2023

  • Synaptic vesicle recovery occurred over time, with single seizures showing faster normalization than serial seizures.
  • Chronic epilepsy models exhibited degenerative synaptic changes, including swollen boutons, reduced vesicle numbers, and vacuoles, suggesting long-term damage.

    • Impact:

    • Findings suggest that synaptic vesicle dysfunction is a key feature of epileptic seizures.
    • The study proposes that degenerative synaptic changes observed in chronic epilepsy may contribute to cognitive deficits, such as epileptic dementia.
    • This research provides insights into the cellular mechanisms underlying epilepsy-related neurological impairments.