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Updated: Jul 14, 2026
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Alcohol can inhibit effect of IL-4 on activated murine B cells
M Aldo-Benson1, L Pratt, J Hardwick
1Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5103.
Abstract:
Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.
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