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Stereoselective synthesis and antimalarial activity of alpha-artelinic acid from artemisinin
R A Vishwakarma1, R Mehrotra, R Tripathi
1Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Journal of Natural Products
|August 1, 1992
Abstract:
alpha-Artelinic acid [8], a potent, stable, and water-soluble antimalarial agent, has been synthesized from artemisinin [1], the sesquiterpene lactone endoperoxide isolated from Artemisia annua. The blood schizontocidal antimalarial activity of alpha-artelinic acid evaluated against Plasmodium knowlesi is also reported.