Related Experiment Video

Updated: Sep 2, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

THE ORIGIN OF THE CELLS IN THE EFFERENT LYMPH FROM A SINGLE LYMPH NODE

J G HALL, B MORRIS

    The Journal of Experimental Medicine
    |June 1, 1965
    PubMed

    The popliteal nodes of sheep were perfused continuously for over 100 hours with a solution containing (3)H-thymidine. The labelling pattern of the lymphocytes in the efferent lymph from the perfused nodes showed that under normal conditions not more than 4 per cent of these lymphocytes were actually produced in the node. The transitional cells, large lymphocytes and cells of the plasma cell series which appeared in the lymph following antigenic stimulation of the node were all produced in the node.

    Keywords:
    DNAEXPERIMENTAL LAB STUDYLYMPHLYMPH NODESLYMPHOCYTESPERFUSIONPHOTOMICROGRAPHYPLASMA CELLSRADIOAUTOGRAPHYSHEEPTHYMIDINETRITIUM

    More Related Videos

    Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice05:59

    Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

    Published on: May 14, 2020

    Isolation of Murine Lymph Node Stromal Cells05:47

    Isolation of Murine Lymph Node Stromal Cells

    Published on: August 19, 2014

    Related Concept Videos

    Detailed Structure and Function of Lymph Nodes01:23

    Detailed Structure and Function of Lymph Nodes

    Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
    From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
    Development of the Lymphatic System01:15

    Development of the Lymphatic System

    The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
    The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
    Primary Lymphoid Organs01:16

    Primary Lymphoid Organs

    Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
    The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
    Cells of the Adaptive Immune Response01:23

    Cells of the Adaptive Immune Response

    The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
    Lymphoid Cells and Tissues01:18

    Lymphoid Cells and Tissues

    Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
    Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
    Lymphatic Vessels and Lymph Transport01:16

    Lymphatic Vessels and Lymph Transport

    Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
    This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.