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Updated: Sep 2, 2026

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
INTERFERON-LIKE ACTIVITY OF EXTRACTS OF HUMAN SPLEEN
Canadian Medical Association Journal
|July 31, 1965
Abstract:
Extracts of human splenic tissue were found to resemble interferon in (a) their physicochemical properties, and (b) their mode of action when tested in vivo in the rabbit, using vaccinia as the challenge virus. The methods used to obtain (1) the crude extract and (2) a partially purified final fraction are described. The latter was found to be non-dialysable, stable over a pH range of 2-11, and relatively heat resistant. On analysis it appeared to be, or was associated with, a glycoprotein.

