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Related Experiment Videos

Enamel ultrastructure in pigmented hypomaturation amelogenesis imperfecta.

J T Wright1, V Lord, C Robinson

  • 1Department of Pediatric Dentistry, University of North Carolina, Chapel Hill.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|October 1, 1992
PubMed
Summary

Hypomaturation amelogenesis imperfecta (AI) is a genetic enamel disorder. This study found that AI enamel contains retained organic material, likely enamel protein, inhibiting normal crystal growth and causing structural defects.

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Area of Science:

  • Biomineralization
  • Dental Enamel Ultrastructure
  • Hereditary Dental Defects

Background:

  • Hypomaturation amelogenesis imperfecta (AI) is a hereditary enamel defect.
  • It is presumed to arise from issues during enamel maturation.
  • Pigmented hypomaturation AI presents unique ultrastructural characteristics.

Purpose of the Study:

  • Characterize enamel ultrastructure in pigmented hypomaturation AI.
  • Investigate enamel crystallite morphology.
  • Determine the distribution and nature of organic material in affected enamel.

Main Methods:

  • Examined autosomal recessive pigmented hypomaturation AI enamel using light, scanning electron, and transmission electron microscopy.
  • Deproteinization of enamel samples using 30% NaOCl or 8 M urea.

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  • Comparison of treated AI enamel with untreated normal enamel.

    • Main Results:

    • AI enamel crystallites showed significant variability in size and morphology.
    • Deproteinization revealed a thick coating on AI crystallites, absent in normal enamel.
    • This coating is presumed to be retained organic material, likely enamel protein.

    Conclusions:

    • Hypomaturation AI is associated with the retention of organic material, primarily enamel protein.
    • Enamel protein retention likely inhibits normal crystallite growth.
    • This inhibition leads to the characteristic crystallite abnormalities seen in hypomaturation AI.