Color chart assisted diagnosis of Raynaud's phenomenon in an unselected hospital employee population

The prevalence of Raynaud's phenomenon (RP) in 750 subjects was assessed by questionnaire, clinical interview, and use of a chart of color photographs taken of hands during attacks of RP. Eighty-three of 600 women (13.8%) and 7 of 150 men (4.7%) reported cold induced digital color changes on the questionnaire, 76 women (12.7%) and 6 men (4%) were diagnosed as having RP at an independent clinical interview, and 3 women could not be assessed using the color chart because of defective color perception. Fifty-four of the remaining 597 women (9%) and 6 of 150 men (4%) were diagnosed as having RP when a positive response to both chart and questionnaire was required. The color chart should be useful in lessening the frequency of false-positive responses and in standardizing the diagnosis for epidemiological surveys.