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[Plasma prolactin levels in normal children from birth to adolescence]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1977
Insights
Neonatal prolactin levels are high in both sexes. Puberty reveals distinct plasma prolactin patterns between boys and girls, indicating sex-specific hormonal changes during adolescence.
Area of Science:
- Endocrinology
- Pediatrics
- Reproductive Biology
Context:
- Understanding hormonal changes in children is crucial for assessing normal development.
- Prolactin, a hormone with diverse functions, has poorly understood developmental patterns in pediatric populations.
Purpose:
- To characterize plasma prolactin levels in normal children from birth through puberty.
- To identify potential sex differences in prolactin secretion during the neonatal period and adolescence.
Summary:
- Plasma prolactin was measured using radioimmunoassay in children at various life stages: cord blood, infancy, childhood, and puberty.
- A significant neonatal prolactin surge was observed in both males and females.
- Longitudinal data revealed distinct prolactin profiles in boys versus girls during puberty.
Impact:
- Provides normative data for prolactin levels in pediatric populations.
- Highlights sex-specific prolactin dynamics during puberty, informing clinical assessment and research.
- Establishes a foundation for further investigation into prolactin's role in child development and puberty.
Abstract:
Plasma prolactin levels were determined by an homologous radio-immuno assay in normal children: in cord blood, at the first day of life, during childhood and along puberty. 1. In both sexes, there is a very important secretion of prolactin during the neonatal period. 2. Longitudinal studies make obvious a different pattern of plasma prolactin in boys and in girls at puberty.