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Human fetal heart development after mid-term: morphometry and ultrastructural study.

H D Kim1, D J Kim, I J Lee

  • 1Department of Histology, College of Medicine, Chung-Ang University, Seoul, South Korea.

Journal of Molecular and Cellular Cardiology
|September 1, 1992
PubMed
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Human fetal heart development shows ongoing myocyte growth and consistent ventricular wall thickness ratios. These findings suggest myocyte development continues post-birth and do not support right ventricular dominance in fetuses.

Area of Science:

  • Cardiovascular Development
  • Human Embryology
  • Cardiac Ultrastructure

Background:

  • Human fetal heart development involves complex cellular and structural changes.
  • Understanding ventricular growth patterns is crucial for diagnosing congenital heart defects.
  • Previous theories suggested right ventricular dominance during fetal development.

Purpose of the Study:

  • To investigate the ultrastructural and morphometric development of human fetal hearts.
  • To analyze ventricular wall thickness, cross-sectional areas, and myocyte development.
  • To evaluate the theory of right ventricular dominance during fetal life.

Main Methods:

  • Ultrastructural and morphometric analysis of 44 human fetal hearts (17-40 weeks gestation).
  • Measurement of ventricular wall thicknesses and interventricular septum.

Related Experiment Videos

  • Computerized image analysis for ventricular cross-sectional areas.
  • Statistical analysis using linear regression and ANOVA.

    • Main Results:

    • Myofibril formation initiated from Z centers, with a transverse tubule system developing later in gestation.
    • Well-developed mitochondria, Golgi complexes, glycogen, and microvessels were observed throughout fetal development.
    • Binucleated myocytes appeared by 32 weeks, suggesting potential cessation of myocyte hyperplasia before birth.
    • Ventricular wall growth and cross-sectional areas showed linear regression with constant left-to-right thickness ratios.
    • No significant morphometric differences were found between left and right ventricles.

    Conclusions:

    • Myocyte development is a continuous process that may extend into the postnatal period.
    • Statistical data do not support the concept of right ventricular dominance in the human fetal heart.
    • The findings provide insights into normal human cardiac development and morphology.