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Urinary bladder function in the tight-skin mouse.

P A Longhurst1, B Eika, R E Leggett

  • 1Division of Urology, University of Pennsylvania School of Medicine, Philadelphia.

The Journal of Urology
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Increased collagen in tight-skin mice bladders did not affect bladder capacity or compliance. Other factors like collagen subtypes and collagen to elastin ratio may be more important for bladder function.

Area of Science:

  • Urology
  • Connective Tissue Biology
  • Animal Models

Background:

  • Tight-skin mice exhibit connective tissue hypertrophy, with increased collagen in various organs.
  • Bladder wall structure and compliance are thought to be influenced by collagen content.
  • Previous studies have not examined bladder characteristics in tight-skin mice.

Purpose of the Study:

  • To investigate bladder collagen content, micturition characteristics, and biomechanical properties in tight-skin mice.
  • To determine the relationship between increased bladder collagen and bladder function.
  • To explore factors influencing bladder distension and compliance.

Main Methods:

  • Assessment of bladder collagen content and concentration in tight-skin mice and age-matched controls.

Related Experiment Videos

  • Evaluation of micturition patterns, including urination volume and frequency.
  • Analysis of length-tension relationships (passive and active) in bladder strips.

    • Main Results:

    • Tight-skin mice bladders showed a 70% increase in collagen content and concentration compared to controls.
    • Bladder mass, protein content, and protein concentration remained similar between groups.
    • Tight-skin mice exhibited increased urination volume and frequency, suggesting a potentially greater functional bladder capacity.
    • No significant changes were observed in passive length-tension curves or active tension development.

    Conclusions:

    • Bladder collagen concentration alone may not be the primary determinant of bladder capacity or compliance.
    • Other factors, such as collagen subtype ratios or the collagen to elastin ratio, might play a more significant role in maintaining bladder distensibility.
    • Further research is needed to elucidate the complex mechanisms governing bladder wall mechanics.