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Absorbable suture improves growth of venous anastomoses
A M Gillinov1, A W Lee, J M Redmond
1Department of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, MD 21205.
Journal of Vascular Surgery
|November 1, 1992
Summary
Absorbable polyglyconate sutures promoted superior growth in pediatric venous anastomoses compared to nonabsorbable polypropylene sutures in a porcine model. This finding is crucial for pediatric vascular surgery and organ transplantation.
Area of Science:
- Pediatric Vascular Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Vascular anastomosis growth is critical in pediatric vascular surgery, particularly for organ transplantation.
- While absorbable sutures aid arterial anastomosis growth, optimal materials for venous anastomoses remain unclear.
Purpose of the Study:
- To investigate the impact of absorbable (polyglyconate) versus nonabsorbable (polypropylene) sutures on venous anastomosis growth in a pediatric porcine model.
Main Methods:
- Bilateral external jugular vein anastomoses were created in piglets using either continuous 8-0 polyglyconate or 8-0 polypropylene sutures.
- Vein diameter and cross-sectional area were assessed via contrast radiography after 6 months.
- Histological examination evaluated suture material presence and degradation.
Main Results:
- Polyglyconate anastomoses exhibited significantly greater cross-sectional area and percentage of growth compared to polypropylene anastomoses.
- Polyglyconate sutures showed partial or complete dissolution, while polypropylene remained identifiable.
- No significant difference in cross-sectional area was observed proximal or distal to the anastomoses.
Conclusions:
- Absorbable polyglyconate sutures facilitate superior growth of venous anastomoses in a pediatric model compared to nonabsorbable polypropylene.
- These findings suggest polyglyconate may be a preferred suture material for pediatric venous reconstruction to support long-term vessel patency and growth.