Alloimmune anti-H-2 mouse sera inhibit human mixed lymphocyte reactions

The inhibitory effect of alloimmune congenic mouse anti-H-2f serum on human mixed lymphocyte cultures was investigated. The anti-H-2 serum tested produced a strong inhibitory effect on human allogeneic MLR. This effect was more pronounced when HLA-A2 positive cells were involved in the MLR. More experiments are needed to substantiate the finding that both stimulator and responder functions of the human lymphocytes are impaired. The anti-H-2 serum also inhibited the human lymphocyte response to PHA.