Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inflammation and pro-inflammatory cytokine].

N Mukaida1

  • 1Department of Pharmacology, Kanazawa University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
PubMed
Summary

Inflammation involves leukocyte infiltration and plasma exudation, leading to granulation tissue. Pro-inflammatory cytokines like IL-1, IL-6, and TNF-alpha orchestrate these inflammatory responses and systemic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individual monitoring for internal exposure of workers in FDNPS.

Annals of the ICRP·2026
Same author

Individual monitoring for external exposure of workers in FDNPS.

Annals of the ICRP·2026
Same author

TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.

Oncogene·2013
Same author

Production of IL-8 and the other cytokines by T cell clones established from the ocular fluid of patients with Behçet's disease.

Ocular immunology and inflammation·2012
Same author

Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma.

Cancer gene therapy·2012
Same author

Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization.

Clinical and experimental immunology·2010

Area of Science:

  • Immunology
  • Pathology

Context:

  • Inflammation is a complex biological response involving cellular infiltration and tissue repair.
  • Systemic effects include fever and elevated acute phase reactants.
  • Mediators produced by cells upon encountering stimuli are responsible for these reactions.

Purpose:

  • To review the roles of key cytokines in the progression of inflammation.
  • To discuss the impact of these cytokines on body temperature, leukocyte infiltration, and acute phase reactant production.

Summary:

  • Inflammatory stimuli trigger the production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha).
  • These cytokines exhibit overlapping functions, amplify each other's production, and form a complex regulatory network.
  • Their collective action accelerates inflammation, influencing pathological and systemic manifestations.

Impact:

  • Understanding the cytokine network is crucial for comprehending inflammatory processes.
  • This knowledge aids in developing targeted therapies for inflammatory diseases.
  • Highlights the central role of cytokines in mediating inflammation and its consequences.

Related Experiment Videos