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[Function, molecular structure and gene expression of interleukin-11 (IL-11/AGIF)]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
Summary
Interleukin-11 (IL-11), also known as adipogenesis inhibitory factor (AGIF), is a cytokine that inhibits fat cell formation. This cytokine also supports other key biological processes like blood cell development and immune responses.
Area of Science:
- * Hematology and Immunology
- * Cell Biology and Biochemistry
Context:
- * Interleukin-11 (IL-11) was identified as a novel cytokine from primate bone marrow stromal cells.
- * Adipogenesis inhibitory factor (AGIF) was independently cloned from human bone marrow stromal cells.
- * The cDNA sequences of IL-11 and AGIF were found to be identical.
Purpose:
- * To characterize the novel cytokine Interleukin-11 (IL-11) and its biological functions.
- * To establish the identity between IL-11 and Adipogenesis inhibitory factor (AGIF).
- * To summarize the diverse biological activities of IL-11/AGIF.
Summary:
- * IL-11/AGIF inhibits adipogenesis in bone marrow-derived preadipocytes.
- * IL-11/AGIF promotes megakaryocytopoiesis (platelet production).
- * IL-11/AGIF supports stem cell proliferation, hepatic acute phase responses, and antibody production.
Impact:
- * Provides a comprehensive overview of the multifaceted roles of IL-11/AGIF.
- * Highlights IL-11's significance in regulating adipogenesis and hematopoiesis.
- * Establishes the dual identity and function of IL-11/AGIF in biological systems.