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[The interaction between neural activity and intracellular pH].

A Komatsu1

  • 1Department of Physiology, Tokyo Women's Medical College.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1992
PubMed
Summary
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This study explores how nervous system cells regulate intracellular pH (pH(i)) and its impact on neural activity. Understanding pH(i) mechanisms is key to comprehending neuronal function and excitability.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Physiology

Context:

  • Intracellular pH (pH(i)) regulation is crucial for nervous system function.
  • Recent advances in measurement techniques have enabled detailed studies.
  • Neurons and glial cells employ buffering and transport mechanisms.

Purpose:

  • To outline the mechanisms of intracellular pH regulation in the nervous system.
  • To discuss the interplay between neural activity and acid-base balance.
  • To emphasize the dynamic changes in pH(i) during neural activity.

Summary:

  • Elucidates mechanisms of intracellular pH regulation in neurons and glial cells, including buffering and acid transport.
  • Explores the interaction between neural activity and acid-base balance.

Related Experiment Videos

  • Highlights how dynamic pH(i) changes affect neuronal electrical properties.

    • Impact:

    • Provides a foundation for understanding neuronal excitability and function.
    • Informs research on neurological disorders associated with pH dysregulation.
    • Advances knowledge of cellular homeostasis in the central nervous system.