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[Acid-base disturbances in hematologic diseases].

S Hoshino1, H Mizoguchi

  • 1Department of Hematology, Tokyo Women's Medical College.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Hematologic diseases can cause acid-base disturbances like lactic acidosis (LA) in leukemia and lymphoma, often linked to liver dysfunction. Multiple myeloma is associated with renal tubular acidosis and a lower anion gap.

Area of Science:

  • Nephrology
  • Oncology
  • Hematology

Context:

  • Acid-base disturbances are common complications in patients with hematologic malignancies.
  • Understanding these metabolic derangements is crucial for patient management.

Purpose:

  • This article discusses the various acid-base disturbances observed in hematologic diseases.
  • It aims to highlight the specific mechanisms and clinical associations of these conditions.

Summary:

  • Lactic acidosis (LA) occurs in leukemia and lymphoma, often associated with liver involvement and impaired hepatic function, suggesting dual causes of increased lactate production and reduced metabolism.
  • Acute tumor lysis syndrome, characterized by electrolyte abnormalities, is seen in lymphoproliferative disorders.
  • Multiple myeloma (MM) is linked to proximal renal tubular acidosis (Fanconi syndrome) and Bence Jones proteinuria, and is recognized for its association with a low anion gap.

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Impact:

  • This review provides insights into the complex interplay between hematologic disorders and acid-base balance.
  • It aids clinicians in recognizing and managing these metabolic complications, potentially improving patient outcomes.