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Related Experiment Videos

[Transgenic mouse and gene targeting].

J Miyazaki1, F Tashiro

  • 1Disease-related Gene Regulation Research, Sandoz, Faculty of Medicine, University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Transgenic mouse technology and gene targeting in mouse embryonic stem cells are powerful tools for medical research. These methods allow for the creation of mice with specifically altered genotypes, providing valuable insights.

Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Context:

  • Transgenic mouse models are crucial for understanding gene function and disease mechanisms.
  • Advancements in gene targeting enable precise genetic modifications in mouse embryonic stem cells.
  • Existing transgenic mice express various genes, including oncogenes, viral genes, and MHC antigens, aiding research.

Purpose:

  • To review the background and recent advances in transgenic mouse technology.
  • To discuss the application of gene targeting in mouse embryonic stem cells for creating genetically modified mice.
  • To highlight the value of these technologies in medical research.

Summary:

  • Transgenic mouse technology allows for the expression of specific genes in mice, facilitating research.

Related Experiment Videos

  • Gene targeting via homologous recombination in mouse embryonic stem (ES) cells enables the generation of mice with precisely altered genotypes.
  • This review covers the foundational principles and recent developments in these powerful genetic engineering techniques.

    • Impact:

    • Transgenic mice and gene-targeted ES cells provide invaluable models for studying complex biological processes and diseases.
    • These technologies accelerate the pace of discovery in medical research and drug development.
    • Understanding these techniques is essential for researchers aiming to create specific genetic alterations in mice for experimental purposes.