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[Altered bone metabolism in db/db mice].

T Hosokawa1

  • 1Third Department of Internal Medicine, Tokyo Medical and Dental University.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study shows that diabetes in db/db mice leads to retarded bone growth and thinner cortical bone. Treatment with the hypoglycemic agent AS-6 improved glucose and calcium levels, suggesting a link between diabetes control and bone health.

Area of Science:

  • Metabolic disorders
  • Bone metabolism
  • Pharmacology

Background:

  • Genetically obese, diabetic db/db mice exhibit altered bone and calcium metabolism.
  • Diabetes progression is associated with retarded bone growth and cortical bone thinning in these mice.

Purpose of the Study:

  • To investigate the effects of a novel hypoglycemic agent, AS-6, on bone and calcium metabolism in diabetic db/db mice.
  • To compare metabolic and bone parameters between treated db/db mice, untreated db/db mice, and lean controls.

Main Methods:

  • db/db mice and lean controls were fed a standard diet (CE-2) for 20 weeks.
  • A separate group of db/db mice received the CE-2 diet supplemented with 0.1% AS-6.
  • Serum glucose and calcium levels, as well as femur weights and dimensions, were analyzed.

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Main Results:

  • db/db mice showed significantly higher serum glucose and calcium levels, lower femur weights, and shorter femur length compared to lean controls.
  • Cortical bone area was significantly smaller in untreated db/db mice, suggesting increased bone resorption.
  • AS-6 treatment reduced serum glucose by 48.6% and serum calcium by 5.2% compared to untreated db/db mice.

Conclusions:

  • Retarded bone growth in db/db mice is linked to diabetes progression.
  • AS-6 demonstrates potential in managing hyperglycemia and improving calcium balance in diabetic mice.
  • Further research is warranted to explore AS-6's therapeutic potential for bone health in diabetes.