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STUDIES OF INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. IV. ESTIMATION OF THE SUPPRESSANT EFFECT OF

S C SKORYNA, T M PAUL, D WALDRON-EDWARD

    Canadian Medical Association Journal
    |August 28, 1965
    PubMed
    Summary
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    Sodium alginate effectively reduces radioactive strontium uptake in the body, ensuring calcium availability. Even low doses significantly decrease radiostrontium absorption into bones, offering a protective dietary strategy.

    Area of Science:

    • Biochemistry
    • Radiological Health
    • Nutritional Science

    Background:

    • Radioactive strontium (Sr-89) poses health risks due to its absorption and bone deposition.
    • Selective suppression of strontium absorption is crucial for maintaining calcium bioavailability.
    • Dietary interventions are explored to mitigate radiostrontium uptake.

    Purpose of the Study:

    • To investigate the efficacy of sodium alginate in suppressing radioactive strontium absorption.
    • To determine the dose-response relationship between sodium alginate and strontium bone uptake.
    • To assess the long-term effects of low-dose sodium alginate on radiostrontium bone deposition.

    Main Methods:

    • Administration of varying concentrations of sodium alginate (1.4%, 12%, 24%) in ingested food.
    Keywords:
    ALGINATESBONE AND BONESCALCIUM ISOTOPESCALCIUM METABOLISMEXPERIMENTAL LAB STUDYINTESTINAL ABSORPTIONMETABOLISMPHARMACOLOGYRADIOMETRYRATSSTRONTIUM ISOTOPES

    Related Experiment Videos

  • Measurement of Sr-89 uptake and bone deposition in laboratory studies and in rats over an extended period.
  • Analysis of the dose-response relationship between Sr-89 dosage and bone uptake in the presence of sodium alginate.

    • Main Results:

    • Sodium alginate demonstrated effective and proportional reduction of Sr-89 uptake under laboratory conditions.
    • A linear relationship was observed between Sr-89 dosage and bone uptake, even with sodium alginate present.
    • Low doses of sodium alginate were sufficient to significantly reduce radiostrontium bone uptake in rats over a long-term study.

    Conclusions:

    • Sodium alginate is an effective agent for selectively suppressing radioactive strontium absorption from the diet.
    • The protective effect of sodium alginate is dose-dependent and maintains proportionality across different intake levels.
    • Long-term administration of low-dose sodium alginate offers a viable strategy to reduce radiostrontium accumulation in bone.