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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
CATALPOL AND METHYLCATALPOL: NATURALLY OCCURRING GLYCOSIDES IN PLANTAGO AND BUDDLEIA SPECIES
The Biochemical Journal
|July 1, 1965
Summary
Catalpol, a glycoside found in Plantago and Buddleia, has been isolated. A new methylcatalpol glycoside was also identified in Buddleia, confirming previous structural suggestions.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
Background:
- Aucubin-type glycosides are found in various plant species.
- Catalpol was previously known to exist as its ester, catalposide.
Purpose of the Study:
- To isolate and identify glycosides from Plantago and Buddleia species.
- To confirm the structures of isolated glycosides using chemical and physical evidence.
Main Methods:
- Isolation of crystalline glycosides from plant extracts.
- Spectroscopic analysis (e.g., n.m.r.) for structural elucidation.
Main Results:
- Catalpol was isolated from Plantago and Buddleia, identical to the known compound.
- A new mono-O-methyl derivative of catalpol, named methylcatalpol, was identified in Buddleia.
- The structures of catalpol and methylcatalpol were confirmed, with methylcatalpol being the 6-O-methyl derivative.
Conclusions:
- Catalpol and its methyl derivative, methylcatalpol, are significant glycosides in Plantago and Buddleia.
- The study confirms and refines the structural understanding of these plant-derived glycosides.
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