Related Experiment Video
Updated: Jul 29, 2026
07:39
A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals
Published on: June 25, 2018
[Detoxication methods in pancreatogenic enzymatic peritonitis].
Klinicheskaia Meditsina
|May 1, 1992
Summary
A differentiated therapeutic approach for acute destructive pancreatitis with enzymatic peritonitis reduced overall lethality by 11%. This strategy involved intensive resuscitation and targeted interventions for endogenic intoxication.
Area of Science:
- Gastroenterology
- Surgical Critical Care
Context:
- Acute destructive pancreatitis is a severe condition.
- Pancreatogenic enzymatic peritonitis significantly increases mortality.
- Syndrome of endogenic intoxication is a common complication.
Purpose:
- To analyze the therapeutic response in patients with acute destructive pancreatitis and pancreatogenic enzymatic peritonitis.
- To evaluate the effectiveness of a differentiated therapeutic approach.
Summary:
- 536 patients with acute destructive pancreatitis and enzymatic peritonitis were treated.
- Intensive resuscitation included protease inhibitors, cytostatic agents, and antibacterial therapy.
- Advanced treatments like forced diuresis, dialysis, and hemosorption were used for severe intoxication.
- Routine surgical intervention was performed.
- A differentiated approach led to an 11% reduction in overall lethality.
Impact:
- Demonstrates the efficacy of a comprehensive, multi-faceted treatment strategy.
- Highlights the importance of managing endogenic intoxication in pancreatitis.
- Provides evidence for improved outcomes in a critical surgical condition.
Related Concept Videos
01:26Enhanced Elimination of Poison
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
01:30Peritoneal Dialysis I: Introduction and Procedure
Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...