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Updated: Aug 12, 2026
14:28
Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
[Immunologic prognostic parameters in infection by the human immunodeficiency virus]
1Servicio de Cuidados Intensivos, Hospital General Universitari de la Vall d'Hebron, Universidad Autónoma de Barcelona.
Medicina Clinica
|October 31, 1992
Summary
Decreased CD4 lymphocytes and interferon-tau production in early-stage HIV infection predict disease progression. These immune markers can help identify patients at higher risk for developing AIDS.
Area of Science:
- Immunology
- Virology
- Clinical Medicine
Background:
- Human immunodeficiency virus (HIV) infection impacts the immune system.
- Identifying prognostic markers is crucial for managing HIV disease progression.
Purpose of the Study:
- To assess quantitative and functional immunologic parameters as predictors of HIV infection progression.
- To evaluate immune markers for their prognostic value in HIV patients.
Main Methods:
- Analyzed CD4/CD8 lymphocyte counts, CD4/CD8 ratio, IL-2 receptors, PHA response, and IFN-tau production in 85 HIV patients across different stages (II, III, IV) and 35 controls.
- Utilized multivariate analysis to identify significant prognostic factors over a 30-month follow-up period.
Main Results:
- Seventeen patients progressed to stage IV (AIDS) during the study.
- A decrease in CD4 lymphocyte count in stage II and reduced IFN-tau production in stages II and III were significantly associated with progression to stage IV.
Conclusions:
- Reduced interferon-tau (IFN-tau) production in stages II and III of HIV infection is a prognostic factor for progression to stage IV (AIDS).
- A decline in CD4 lymphocyte count during stage II of HIV infection also indicates a higher risk of progressing to stage IV.
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