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Effect of lithium on the double-quantum behavior of 23Na in normal human erythrocytes
R P Gullapalli1, R M Hawk, R A Komoroski
1Department of Electronics & Instrumentation, University of Arkansas, Little Rock 72204.
Abstract:
The double-quantum behavior of 23Na in the presence of different concentrations of Li in human erythrocytes was investigated. The 23Na double-quantum signal was quenched in both the extracellular and the intracellular compartments with increasing concentration of Li in each compartment, along with an increase in the 23Na T1 both intra- and extracellularly. Some extracellular quenching could be observed at the near therapeutic concentration of 2 mM Li. The ratio of slow to fast spin-spin (T2) relaxation times, obtained from the dependence of the double-quantum signal on creation time, approached unity at an overall Li concentration of 40 mM. These results provide evidence that Li and Na compete for both intra- and extracellular binding sites in erythrocytes.