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[Penicillin resistance in Streptococcus pneumoniae strains].
1Hacettepe Universitesi Tip Fakültesi Mikrobiyoloji Anabilim Dali.
Mikrobiyoloji Bulteni
|October 1, 1992
Summary
Penicillin resistance in Streptococcus pneumoniae is a growing concern, with significant proportions of both adult and pediatric isolates showing resistance. Antibiotic susceptibility testing is crucial for effective treatment and avoiding therapeutic failure.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Streptococcus pneumoniae is a leading cause of bacterial infections worldwide.
- Penicillin resistance in S. pneumoniae poses a significant challenge to public health.
- Disk diffusion and agar dilution methods are standard techniques for assessing antibiotic susceptibility.
Purpose:
- To evaluate the susceptibility of Streptococcus pneumoniae isolates to penicillin using both disk diffusion and agar dilution methods.
- To compare the resistance patterns observed in adult and pediatric isolates.
- To highlight the importance of routine antibiotic susceptibility testing for pneumococcal infections.
Summary:
- A total of 87 Streptococcus pneumoniae strains were tested for penicillin susceptibility.
- Disk diffusion revealed varying resistance levels in adult (6.3% high-level resistance) and pediatric (33.4% high-level resistance) isolates.
- Agar dilution showed lower high-level resistance rates (0% in adults, 20.8% in children) but confirmed significant penicillin resistance.
Impact:
- Findings underscore the need for routine antibiotic susceptibility testing of all pneumococcal isolates.
- Accurate susceptibility data is essential to guide appropriate antibiotic selection and prevent therapeutic failure.
- This study contributes to understanding the epidemiology of penicillin resistance in S. pneumoniae.