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[Innovative elastomeric bio-adhesive (pup-201) synthesized by urethane-prepolymer]
1First Department of Surgery, Shiga University Medicine Science, Otsu, Japan.
Nihon Geka Gakkai Zasshi
|October 1, 1992
Summary
PUP-201, a novel biomaterial, shows superior adhesive strength and tissue compatibility compared to fibrin adhesives. It is a promising sealant and hemostatic agent for vital organs.
Area of Science:
- Biomaterials Science
- Surgical Adhesives
- Tissue Engineering
Background:
- Current surgical adhesives often lack sufficient strength or biocompatibility for vital organ applications.
- Fibrin-based adhesives have limitations in terms of adhesive strength and curing time.
Purpose of the Study:
- To evaluate the properties of PUP-201 for potential use in vital organs.
- To compare PUP-201 with existing fibrin and synthetic adhesives.
Main Methods:
- Assessed adhesive strength (initial and wet), curing time, and elongation rate of PUP-201.
- Compared PUP-201 properties with commercial fibrin adhesives.
- Evaluated shear strength on pig skin and small intestine using JIS K6850.
- Conducted toxicity tests on pig skin.
- Performed practical hemostasis and sealing tests on dog liver and lung sections.
Main Results:
- PUP-201 exhibited 40-150 times greater adhesive strength than fibrin adhesives.
- Curing time was 50 seconds with an elongation rate of 150%, similar to intestinal tissue.
- Adhesive strength on pig skin was 2.0-2.8 kg/cm², and 0.4-1.0 kg/cm² on small intestine.
- No antimicrobial activity or toxicity was observed.
- Successful hemostasis and sealing were achieved in ex vivo liver and lung models.
Conclusions:
- PUP-201 demonstrates excellent adhesive strength, appropriate elasticity, and good biocompatibility.
- It is a highly effective material for adhesion, hemostasis, and sealing of vital tissues.
- PUP-201 shows significant potential as a superior alternative to current surgical adhesives.