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[Modeling in biology. Structured analysis of intracellular calcium oscillations in electrically non-excitable cells]
1AG Medizinische Physik und Elektronenmikroskopie, Institut für Immunobiologie der Universität, Freiburg, FRG.
Die Naturwissenschaften
|July 1, 1992
Abstract:
In this paper a systematic approach to the mathematical modeling of intracellular Ca2+ oscillations is introduced. After a structured analysis a stochastic model of the system is derived which is numerically tractable by means of a stochastic simulation. A critical discussion of theoretical models for Ca2+ oscillations reveals that not all of the proposed mechanisms are consistent with experimental data. In addition, a model for oscillatory calcium waves is presented. Uncovering these mechanisms facilitates the design of anti-mitotic drugs interfering with Ca2+ metabolism.