Related Experiment Video

Updated: Sep 1, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

Local complications of BCG vaccination in pre-school children and new-born babies

C T HSING

    Bulletin of the World Health Organization
    |January 1, 1954
    PubMed

    Insights

    BCG vaccination complications are common in Taiwanese infants and young children. Regional glandular enlargement and abscesses occur frequently, potentially undermining public trust in this vital immunization.

    Area of Science:

    • Pediatrics
    • Immunology
    • Public Health

    Background:

    • Bacillus Calmette-Guérin (BCG) vaccination is a key public health intervention for preventing tuberculosis.
    • Local complications following BCG vaccination require careful monitoring, especially in pediatric populations.

    Purpose of the Study:

    • To discuss the local complications of BCG vaccination in Taiwanese infants and pre-school children.
    • To highlight the incidence and implications of adverse reactions to BCG vaccination.

    Main Methods:

    • Review of local BCG vaccination complication data in Taiwan.
    • Analysis of complication frequencies in different age groups (new-borns vs. pre-schoolers).

    Main Results:

    • Severe local reactions at the vaccination site are infrequent.
    • High frequency of regional glandular enlargement and abscess formation observed.
    • Complication rates are particularly concerning in new-born babies.

    Conclusions:

    • The high incidence of regional complications poses a risk to the perceived safety and effectiveness of BCG vaccination.
    • There is a need to address these local BCG vaccine reactions to maintain public confidence in immunization programs.

    Keywords:
    BCG VACCINATION/complications

    More Related Videos

    Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System10:11

    Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System

    Published on: January 31, 2018

    Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria06:38

    Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

    Published on: December 8, 2023

    Related Concept Videos

    Development of Immunocompetence01:22

    Development of Immunocompetence

    The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
    The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
    Subsequent T...
    Vaccinations01:51

    Vaccinations

    Overview
    Chickenpox01:20

    Chickenpox

    Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
    Smallpox01:24

    Smallpox

    Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
    Bacterial Meningitis I: Introduction01:22

    Bacterial Meningitis I: Introduction

    Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
    Development of Human Microbiota01:30

    Development of Human Microbiota

    The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...