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Related Experiment Videos

Antiviral agents.

D H Watts1

  • 1Department of Obstetrics and Gynecology, University of Washington, Seattle.

Obstetrics and Gynecology Clinics of North America
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Antiviral medications for gynecologic infections are limited and can be toxic. Acyclovir and zidovudine are options for specific viral infections in pregnant women, while others are rarely used.

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Area of Science:

  • Gynecology
  • Virology
  • Pharmacology

Background:

  • Antiviral agents are less numerous and often more toxic than antibacterial agents.
  • Limited antiviral options exist for gynecologic infections.
  • Toxicity is a significant concern with available antiviral drugs.

Purpose of the Study:

  • To review the use of antiviral agents in gynecology.
  • To identify antiviral medications indicated for pregnant women.
  • To highlight antiviral agents not recommended during pregnancy.

Main Methods:

  • Literature review of antiviral agents used in gynecology.
  • Analysis of drug indications for pregnant women.
  • Assessment of contraindications for antiviral use in pregnancy.

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Main Results:

  • Acyclovir is used for herpes simplex virus and may be indicated in pregnant women with disseminated herpes.
  • Zidovudine is indicated for pregnant women with human immunodeficiency virus infection and low CD4 counts.
  • Ganciclovir, vidarabine, ribavirin, amantadine, didanosine, and foscarnet have limited gynecologic indications and are not recommended in pregnancy.

Conclusions:

  • Antiviral therapy in gynecology is restricted due to limited drug availability and potential toxicity.
  • Specific antiviral agents like acyclovir and zidovudine have defined roles in managing viral infections during pregnancy.
  • Several antiviral drugs are contraindicated in pregnancy due to safety concerns.