Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The chromosome complement of human gametes.

Oxford Reviews of Reproductive Biology

|January 1, 1992

Summary

Observed rates of chromosomally abnormal sperm often exceed predicted rates, particularly for structural abnormalities, suggesting preparation artifacts. Discrepancies in trisomy 21 and sex chromosome abnormalities highlight potential issues in sperm analysis and early pregnancy loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Male breast cancer, age and sex chromosome aneuploidy.

British journal of cancer·2013

Same author

Self-mixing flow sensor using a monolithic VCSEL array with parallel readout.

Optics express·2010

Same author

Renewable resources as a key to green chemistry.

Communications in agricultural and applied biological sciences·2010

Same author

Molecular sieve properties of mesoporous silica with intraporous nanocarbon.

Chemical communications (Cambridge, England)·2010

Same author

Cancer risk in patients with constitutional chromosome deletions: a nationwide British cohort study.

British journal of cancer·2008

Same author

Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMR1 haplotypes.

Human mutation·2007

Area of Science:

Human Genetics
Reproductive Biology
Cytogenetics

Background:

Accurate assessment of chromosomally abnormal gametes is crucial for understanding reproductive outcomes.
Previous studies have predicted rates of chromosomal abnormalities in sperm based on various models.

Purpose of the Study:

To compare observed rates of chromosomally abnormal sperm with predicted rates.
To investigate discrepancies for major abnormality classes and specific trisomies.

Main Methods:

Analysis of observed chromosomal abnormality rates in sperm.
Comparison with predicted rates for structural abnormalities and trisomies (e.g., trisomy 21, sex chromosomes).
Evaluation of potential explanations including preparation artifacts and early pregnancy loss.

Main Results:

Observed abnormality rates in sperm generally exceed predicted rates, except for polyploidy.
Structural abnormalities show a significant excess, suggesting preparation artifacts.
Trisomy 21 and sex chromosome abnormalities are overrepresented compared to predictions, with potential links to early post-zygotic loss, though preparation quality is a concern.

Conclusions:

Significant discrepancies exist between observed and predicted rates of chromosomally abnormal sperm.
Preparation artifacts likely contribute to the high rates of observed structural abnormalities.
Further research is needed to clarify the role of sperm aneuploidy in early pregnancy loss and improve diagnostic accuracy.

Related Experiment Videos