Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonprescription ibuprofen: side effect profile.

S A Furey1, J A Waksman, B H Dash

  • 1Medical Department, Whitehall Laboratory, New York, NY 10017-4076.

Pharmacotherapy
|January 1, 1992
PubMed
Summary

Single doses of nonprescription ibuprofen are safe and well-tolerated for common pain relief. Its side effect profile is comparable to acetaminophen and placebo, making it a reliable choice for consumers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.

Cephalalgia : an international journal of headache·2000
Same author

The safety profile of nonprescription ibuprofen in multiple-dose use: a meta-analysis.

Journal of clinical pharmacology·1999
Same author

Brompheniramine maleate: a double-blind, placebo-controlled comparison with terfenadine for symptoms of allergic rhinitis.

American journal of rhinology·1998
Same author

Brompheniramine, loratadine, and placebo in allergic rhinitis: a placebo-controlled comparative clinical trial.

Journal of clinical pharmacology·1998
Same author

A double-blind, placebo-controlled study of the effectiveness and safety of nizatidine in the prevention of postprandial heartburn.

Archives of internal medicine·1997
Same author

Nonprescription ibuprofen and acetaminophen in the treatment of tension-type headache.

Journal of clinical pharmacology·1996

Area of Science:

  • Pharmacology
  • Clinical Trials
  • Pain Management

Background:

  • Nonprescription analgesics are frequently used for self-diagnosed conditions.
  • Evaluating the safety of over-the-counter pain relievers is crucial for public health.

Purpose of the Study:

  • To assess the safety and side effect profile of single doses of nonprescription-strength ibuprofen.
  • To compare ibuprofen's safety against acetaminophen and placebo in treating common painful conditions.

Main Methods:

  • Conducted 15 double-blind, randomized, controlled trials.
  • Included participants receiving ibuprofen (200 or 400 mg), acetaminophen (650 or 1000 mg), or placebo.
  • Monitored and compared reported side effects across all treatment groups.

Main Results:

  • Overall side effect frequencies were similar: ibuprofen (2.4%), acetaminophen (3.2%), and placebo (2.1%).
  • Central nervous system symptoms and upper gastro-intestinal upset occurred at comparable rates across all groups.
  • No significant differences in side effect profiles were observed between ibuprofen, acetaminophen, and placebo.

Conclusions:

  • Single doses of nonprescription ibuprofen are well-tolerated by patients.
  • Ibuprofen demonstrates a side effect profile indistinguishable from acetaminophen and placebo.
  • Nonprescription ibuprofen is a safe option for managing common painful conditions.

Related Experiment Videos