Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Theophylline-mexiletine interaction: a case report.

J D Kendall1, M M Chrymko, B E Cooper

  • 1Pharmacy Service, Department of Veterans Affairs Medical Center, Erie, PA 16504.

Pharmacotherapy
|January 1, 1992
PubMed
Summary

Theophylline toxicity can occur in patients with chronic obstructive pulmonary disease (COPD) when starting mexiletine due to drug interactions. Stopping mexiletine improved theophylline clearance, resolving toxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment·2010
Same author

Fact versus opinion in the judgment on fosphenytoin articles.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·1997
Same author

A perspective on aprotinin.

The Annals of pharmacotherapy·1996
Same author

Computerized pharmacokinetics on an institutional clinical information system.

Pharmacy practice management quarterly·1995
Same author

Brainstem auditory evoked potentials in liver transplant candidates.

The Nebraska medical journal·1995
Same author

Strategic planning for residency training programs.

Pharmacy practice management quarterly·1995

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Drug Interactions

Background:

  • Theophylline and mexiletine are medications used in managing chronic obstructive pulmonary disease (COPD) and cardiac arrhythmias.
  • Both drugs share common metabolic pathways, raising concerns about potential drug-drug interactions.

Observation:

  • A patient with COPD and arrhythmias, already on theophylline, developed theophylline toxicity shortly after initiating mexiletine therapy.
  • Clinical monitoring revealed a significant increase in theophylline levels during concurrent mexiletine use.

Findings:

  • The co-administration of theophylline and mexiletine resulted in a clinically significant drug interaction.
  • Discontinuation of mexiletine led to a marked improvement in theophylline clearance and resolution of toxicity symptoms.

Related Experiment Videos

Implications:

  • Clinicians should exercise caution when prescribing theophylline and mexiletine concurrently, especially in patients with COPD.
  • Awareness of shared metabolic pathways is crucial for predicting and preventing adverse drug events.
  • Therapeutic drug monitoring and dose adjustments may be necessary to manage this interaction safely.